The MRC has awarded ?10.6 million to projects to develop better models of human disease, including diabetes, stroke, heart disease and age-related macular degeneration. Twenty research groups will benefit and several of the projects will involve collaborations with industry.
Award winner: G. Bates
Institution: King's College London
Value: ?730,518
Identification and cross-validation of early stage phenotypes in mouse models of Huntington's disease
Award winner: N. Thapar
Institution: University College London
Value: ?607,936
Using key models for developing stem-cell-based therapies for aganglionic gut disorders
Award winner: P. Cowen
Institution: University of Oxford
Value: ?382,100
Impaired neural responses to the sight and taste of chocolate: A model of anhedonia in depression
Award winner: M. Little
Institution: University of Birmingham?
Value: ?378,712?
Towards robust animal models of ANCA-associated vasculitis
Award winner: D. T. Shima
Institution: Institute of Ophthalmology
Value: ?348,032
Qualifying mouse models of spontaneous, progressive age-related macular degeneration
Award winner: W. P. Duprex
Institution: Queen's University Belfast
Value: ?897,700
Illuminating childhood respiratory infections: from viral diseases to vaccine delivery
Award winner: R. R. Ali
Institution: Institute of Ophthalmology
Value: ?435,316
Pathology and treatment of mouse models of dominant retinal disease
Award winner: O. Albagha
Institution: University of Edinburgh
Value: ?371,532
Characterisation and therapeutic intervention of two novel mouse models of Paget's disease of bone
Award winner: A.M. Gray
Institution: University of Oxford
Value: ?489,472
An outcomes model for type 2 diabetes
Award winner: V. Sboros
Institution: University of Edinburgh
Value: ?710,544
Development of contrast enhanced ultrasonography using the sheep ovarian model of microvascular regulation
Award winner: D. Abraham
Institution: University College London
Value: ?497,356
Genetic models for connective tissue disease, scarring and fibrosis
Award winner: C. Haslett
Institution: University of Edinburgh
Value: ?634,940
Multimodal smart imaging of critical inflammatory processes in murine models of pulmonary fibrosis
Award winner: M. Bailly
Institution: Institute of Ophthalmology
Value: ?497,792
Combined in vitro and ex vivo model to design novel combinatorial strategies for the modulation of scarring
Award winner: J.M. Collinson
Institution: University of Aberdeen
Value: ?436,992
The pma mouse and the developmental basis of congenital talipes equinovarus (clubfoot)
Award winner: S. M. Allan
Institution: University of Manchester
Value: ?639,784
Subarachnoid haemorrhage as a valid model for stroke
Award winner: K. Smith
Institution: Institute of Neurology
Value: ?761,372
To develop therapies and a strategy for their translation to treat early lesions in multiple sclerosis
Award winner: S.C. Stanford
Institution: University College London
Value: ?622,644
NK1R knockout mouse model and human genetics of attention deficit hyperactivity disorder
Award winner: K. P. Moore
Institution: University College London
Value: ?415,488
Characterising the D-galactosamine rat model of hepatorenal syndrome
Award winner: N. Smith
Institution: University of Oxford
Value: ?376,724
Dissecting heart failure mechanisms by integrating in vivo and in vitro data within customised silico models
Award winner: K. Wood
Institution: University of Oxford
Value: ?395,784
Humanised mouse models.