John von Neumann University

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Czech Republic, Brno

Department:?Marek Mráz Research Group?–?Central European Institute of Technology
Deadline:?15 Jan 2025
Start date:?early 2025 (to be negotiated)
Job type:?full-time
Job field:?Science and research

Come to CEITEC MU in Brno and join us!

We are passionate molecular biologists at CEITEC looking for

Postdoctoral Researcher

in?Role Of Transcription Factors In Onset And Progression Of B-Cell Malignancies

About this position:

You will work in a?team of young investigators that challenge major problems in the field of hematology. We do basic and translational science, but with the objective to help patients in the future (we have access to primary samples with hem. malignancies, and mouse models).

Transcription factors (TFs) regulate cell growth, development, and hematopoietic differentiation. Disruption of transcription mechanisms can lead to blood cell malignancies, including chronic lymphocytic leukemia (CLL) and other B-cell cancers. Abnormal TF function, caused by dysregulation or genomic aberrations, often activates oncogenes through deregulated chromatin structures and altered enhancer/promoter activity in CLL. Post-translational modifications of TFs due to leukemia microenvironment signaling also contribute to disease progression.

This project explores the role of candidate TFs in B-cell malignancies, focusing on CLL, and evaluates targeted therapies using TF inhibitors or chromatin regulators. Several TFs potentially regulate B-cell survival, proliferation, and immune crosstalk. The PhD student will study these using genome editing (CRISPR), RNA sequencing, primary samples, and in vitro/in vivo mouse models, with implications for understanding therapy resistance.

The candidate profile:


	Motivated smart person with "drive" to work independently, but also willing to learn from other people in the lab and collaborate
	Having degree in Molecular biology, Biochemistry, or similar field and have deep interest in molecular biology and cancer cell biology


What you will learn and do:


	Think and work independently as a?scientist, design experiments and formulate hypothesis
	Write of abstracts and papers (and course in grant writing and presentation of data)
	Attend conferences to present your research
	Spend 1-2 months visit(s) in collaborating labs in Europe or US
	Collaborate with experts in wet lab research and bioinformatics
	Critically analyze scientific data (regular journal clubs)
	Classical and novel methods of molecular biology (e.g. RNAseq, Crispr, Cut&Tag, mouse mdoels, immunoblotting, flow cytometry, qRT-PCR, cell cultures, cloning), and you will use our in vitro models for microenvironmental interactions, and artificial activation/inhibition signalling pathways to decipher the gene regulatory loops
	Supervise students, if interested


?What we provide to you:?


	Open access to CEITEC MU core facilities with state-of-the-art equipment and experienced staff
	Full contract for Post-Docs with competitive salary (funded by ERC grant)
	Flexible working hours
	Support for further education and professional development
	Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports at the campus
	Kindergarten Elánek in Campus
	Support in these areas:
	
		Welcome Office service?before and after arrival
		Grant Office?support
		Postdoc Peer Committee
		CEITEC events?–?workshops, conferences, lectures, training, family gathering?etc.
		More at?Why work at CEITEC MU?
	
	


How to apply?

Application deadline:?15.1.2025

Start date: early 2025?(to be negotiated)

Contact the PI and submit a?CV by email to:?marek.mraz2@email.cz


Masaryk University

Hong Kong

Ref.:?530750
Work type:?Full-time
Department:?School of Public Health (22400)
Categories:?Senior Research Staff & Post-doctoral Fellow

Applications are invited for appointment as?Research Officer in the School of Public Health (Ref.: 530750),?to commence as soon as possible on a one-year temporary term or two-year fixed-term basis, with the possibility of renewal subject to funding availability and satisfactory performance.

Applicants should possess a Ph.D. degree in epidemiology, biostatistics, public health, or a related discipline, with at least 5 years of relevant work experience. They should have solid research experience in communicable and/or non-communicable diseases, and a track record of high-quality impactful research demonstrated by publications and/or external grants. They must be competent in statistical software packages, including R, for data analysis. They should have an excellent command of written and spoken English and Chinese (including Cantonese and Putonghua). They should be organized, responsible, detail-minded, self-motivated, and able to work independently as well as in a multidisciplinary team.

The appointee will lead a project on the health economic evaluation of cancer prevention strategies. He/She will also be responsible for fieldwork using large language models (LLMs) in real-world healthcare settings. He/She will supervise junior research staff and students; develop his/her own research programme; and write scientific publications, grant proposals and reports. He/she would also be assigned teaching duties for undergraduate and postgraduate students, and perform other duties as assigned. Working off-campus may be required. Information about the School can be obtained at?http://sph.hku.hk.

A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits. The appointment on fixed terms will attract a contract-end gratuity and University contribution to a retirement benefits scheme, totalling up to 15% of the basic salary. Housing benefits will be provided as applicable.

The University only accepts online applications for the post. Applicants should apply online and upload an up-to-date CV, and research publication list. Review of applications will commence on January 1, 2025, and continue until?February 28, 2025, or until the post is filled, whichever is earlier.


The University of Hong Kong

India, Delhi

Overview

The University of Southampton, in partnership with Oxford International Education Group (OIEG), is launching its first international campus in India, located in Gurgaon, Delhi. This initiative is a response to India's New Education Policy and represents a significant investment in transnational education. The new campus aims to provide Indian students with the opportunity to earn a globally recognised degree without leaving the country.

Job purpose

The role holder’s contribution will be central to delivery and support of teaching, learning and assessment, across Economics for the University of Southampton Delhi.

The role holder will teach at undergraduate and postgraduate level and engage in other necessary educational activities to ensure successful delivery of degree programmes. Once teaching activities are embedded and successful the role holder will undertake research and knowledge exchange in line with the campus’s research strategy.

The role holder will undertake leadership, management and engagement activities and will demonstrate collegiality by ensuring ‘Southampton Behaviours’ are embedded within their ways or working.

They will be committed to high-quality education and support of learning and to building a vibrant student experience and community. Visible and collegiate, the role holder will be expected to contribute to all aspects of the campus’s activities including student recruitment and outreach.

For further details and how to apply click?here.


University of Southampton

Overview

The University of Southampton, in partnership with Oxford International Education Group (OIEG), is launching its first international campus in India, located in Gurgaon, Delhi. This initiative is a response to India's New Education Policy and represents a significant investment in transnational education. The new campus aims to provide Indian students with the opportunity to earn a globally recognised degree without leaving the country.

?Job purpose

The role holder’s contribution will be central to delivery and support of teaching, learning and assessment, across Business for the University of Southampton Delhi.?

The role holder will teach at undergraduate and postgraduate level and engage in other necessary educational activities to ensure successful delivery of degree programmes. Once teaching activities are embedded and successful the role holder will undertake research and knowledge exchange in line with the campus’s research strategy.

The role holder will undertake leadership, management and engagement activities and will demonstrate collegiality by ensuring ‘Southampton Behaviours’ are embedded within their ways or working.

They will be committed to high-quality education and support of learning and to building a vibrant student experience and community. Visible and collegiate, the role holder will be expected to contribute to all aspects of the campus’s activities including student recruitment and outreach.

For further information and details on how to apply please visit the following link?here


Ref.:?530885
Work type:?Full-time
Department:?Department of Sociology (30400)
Categories:?Senior Research Staff & Post-doctoral Fellow

Applications are invited for appointment as?Post-doctoral Fellow in the Department of Sociology?(Ref.: 530885), to commence as soon as possible for one year.

Applicants should possess a Ph.D. degree in the Social Sciences, Social Epidemiology or Public Health, or related disciplines. Experience in conducting demographic research; with good research record on the social determinants of health among older adults, with particular expertise on disability and housing, would be an advantage. ?Applicants should have a high level of competency in using statistical software packages with evidence of working collaboratively across organisational boundaries and with other disciplines. They should have good knowledge of data harmonization and statistical analysis and research experience in handling longitudinal data analysis. ?Proficiency in written English; excellence in management and statistical skills; ability to work independently.?

The appointees will assist in planning, managing, coordinating, and implementing research activities on the research projects; oversee data collection, data analysis and draft reports, perform any other relevant tasks as assigned, publication and collaborative research opportunities are available.?

A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.?

The University only accepts online application for the above posts. Applicants should apply online and upload an up-to-date CV, a covering letter stating their research background, provide the name and contact information of three referees on the online application form. Review of applications will start as soon as possible and continue until?January 23, 2025, or until the post is filled whichever is earlier.


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John von Neumann University